Ly-6G Monoclonal Antibody (1A8-Ly6g), APC-eFluor™ 780 (47-9668-82) (2024)

FAQs

What disease is diagnosed with monoclonal antibodies? ›

In the simplest test monoclonal antibodies to a known pathogen are added to a sample of an unknown pathogen. If the antibodies attach to antigens and make cells clump together, then the unknown pathogen is identified as the monoclonal antibody pathogen.

Monoclonal antibodies are clones of your body's antibodies that are made in a laboratory, meant to stimulate your immune system. Monoclonal antibodies as therapies are more targeted than some other types of treatments and have been more successful at treating some types of diseases, including some cancers.

Ly6G Antibody - A Marker for Monocytes, Granulocytes and Neutrophils.

Listen to pronunciation. (MAH-noh-KLOH-nul AN-tee-BAH-dee) A type of protein that is made in the laboratory and can bind to certain targets in the body, such as antigens on the surface of cancer cells.

Monoclonal antibodies are a class of drugs used to treat inflammatory autoimmune disorders (conditions in which the immune system attacks the healthy parts of the body and causes pain, swelling, and damage), skin disorders, certain types of arthritis (such as rheumatoid arthritis, psoriatic arthritis, juvenile ...

Some mAbs can have side effects that are related to the antigens they target. For example: Bevacizumab (Avastin) is an mAb that targets a protein called VEGF that affects tumor blood vessel growth. It can cause side effects such as high blood pressure, bleeding, poor wound healing, blood clots, and kidney damage.

Flagging cancer cells.

Some immune system cells depend on antibodies to locate the target of an attack. Cancer cells that are coated in monoclonal antibodies may be more easily detected and targeted for destruction.

We have characterized three types of monoclonal antibodies, namely: (1) antibodies that bind to NGF and inhibit its binding to target cells and its biological activity in culture (type A); (2) antibodies that bind to and precipitate NGF but do not inhibit its binding to target cells or its biological activity (type B); ...

Monoclonal antibody therapy must be administered within 7 days of symptom onset. Virus Antibody Spike protein Antibodies block the virus from entering the cell or enable it to be destroyed.

Ly6c is an antigen commonly used to differentiate between classical and non-classical monocytes/macrophages. Here we show its potential as a marker of the mouse vasculature, particularly of the retinal vascular plexuses.

What do Ly6C high monocytes do? ›

Monocytes expressing high levels of Ly6C (Ly6Chi monocytes) have proinflammatory and antimicrobial functions and express high levels of C-C che- mokine receptor 2 (CCR2) and low levels of CX3C chemo- kine receptor 1 (CX3CR1; CCR2hiCX3CR1low).

Cell Markers

Neutrophils can be distinguished from other granulocytes based on the expression of both CD15 and CD16/FcγRIII and a lack of CD14. In addition, CD66b/CEACAM-8, CD11b/Integrin alpha M, CD33, and myeloperoxidase are other markers that can be used to identify neutrophils.

Monoclonal antibodies (mAbs) can be made in animals immunized with purified protein, peptides, or bacterial or mammalian fusion proteins. The majority of monoclonal antibodies are made using fusion proteins because they can be produced in large quantities and most closely resemble, or are identical to, native protein.

Serum protein electrophoresis (SPEP) is a test that measures the antibodies in the blood and can find a monoclonal antibody. Another test, called immunofixation or immunoelectrophoresis, is used to determine the exact type of abnormal antibody (IgG. IgA or some other type).

The FDA authorized the use of these monoclonal antibody therapies to treat mild-to-moderate COVID-19 in adults and pediatric patients when both of these apply: They have a positive COVID-19 test result. They're at high risk for progressing to severe COVID-19, hospitalization, or both.

Monoclonal antibodies have two main applications - diagnostic and therapeutic. For diagnosis, they are used in assays and imaging to detect hormones, tumors, infections, and other biomarkers.

Monoclonal gammopathies are conditions in which abnormal proteins (antibodies) are found in the blood. These proteins are made from a small number of plasma cells in the bone marrow.